Tourette syndrome, associated conditions and the complexities of treatment
Identifieur interne : 000414 ( Main/Exploration ); précédent : 000413; suivant : 000415Tourette syndrome, associated conditions and the complexities of treatment
Auteurs : Mary M. Robertson [Royaume-Uni]Source :
- Brain [ 0006-8950 ] ; 2000-03.
English descriptors
- KwdEn :
- 5-HT = 5-hydroxytryptamine, ADHD = attention deficit hyperactivity disorder, BNF = British National Formulary, CCEI = Crown Crisp Experimental Index, DBT = double-blind trial, DSMs = Diagnostic and Statistical Manuals, EPSE = extrapyramidal side-effect, GAD = generalized anxiety disorder, MDD = major depressive disorder, NMS = neuroleptic malignant syndrome, NOSI = non-obscene complex socially inappropriate behaviours, OCB = obsessive–compulsive behaviour, OCD = obsessive–compulsive disorder, OCS = obsessive–compulsive symptoms, PANDAS = paediatric autoimmune neuropsychiatric disorders associated with group A β-haemolytic streptococcal infections, SIB = self-injurious behaviour, SSRI = selective serotonin reuptake inhibitor, TCA = tricyclic antidepressant, TD = tardive dyskinesia, TS = Tourette syndrome, Tourette syndrome, YGTSS = Yale Global Tic Severity Scale, clinical phenomenology, psychopathology, treatment.
Abstract
Tourette syndrome (TS) is characterized by multiple motor tics plus one or more vocal (phonic) tics, which characteristically wax and wane. It can no longer be considered the rare and bizarre syndrome that it was once thought to be. The concepts surrounding TS, and our understanding of it, are also becoming increasingly complex and, in some individuals, TS is now recognized to be associated with a wide variety of associated behaviours and psychopathologies. It is suggested that TS is heterogeneous from a variety of standpoints including clinical presentation and psychopathology, and thus neuropharmacological responses and possibly even aetiological and genetic mechanisms. In this paper, mention is made of recent findings in epidemiology and genetics, highlighting the complexities of the disorder; these have been chosen because findings in both areas have clinical and management implications. The literature on the clinical manifestations, associated behaviours, psychopathology (and/or comorbid conditions) and management, in particular, is reviewed in detail.
Url:
DOI: 10.1093/brain/123.3.425
Affiliations:
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Robertson</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry and Behavioural Sciences, University College and The National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Professor Mary M. 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It can no longer be considered the rare and bizarre syndrome that it was once thought to be. The concepts surrounding TS, and our understanding of it, are also becoming increasingly complex and, in some individuals, TS is now recognized to be associated with a wide variety of associated behaviours and psychopathologies. It is suggested that TS is heterogeneous from a variety of standpoints including clinical presentation and psychopathology, and thus neuropharmacological responses and possibly even aetiological and genetic mechanisms. In this paper, mention is made of recent findings in epidemiology and genetics, highlighting the complexities of the disorder; these have been chosen because findings in both areas have clinical and management implications. The literature on the clinical manifestations, associated behaviours, psychopathology (and/or comorbid conditions) and management, in particular, is reviewed in detail.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name></region><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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